Kininogen (High Molecular Weight)

Description

Kininogen (High Molecular Weight)

High Molecular Weight Kininogen (HK) is a multifunctional plasma glycoprotein involved in the intrinsic coagulation pathway, inflammation, and angiogenesis. This 120 kDa protein serves as a cofactor for prekallikrein activation and bradykinin release, and is increasingly studied for its role in vascular biology, neuroinflammation, and cancer progression.

HK is cleaved into HKa (cleaved kininogen), which exhibits antiangiogenic properties and modulates immune responses. This reagent is supplied as a biotechnology-grade solution, filtered through 0.22 m membranes and prepared in ultrapure water. It is suitable for use in protease binding studies, endothelial assays, and mechanistic investigations of the kallikrein-kinin system.

Key Features:

• Human-derived high molecular weight kininogen, 120 kDa
• Supplied as a filtered solution in ultrapure water
• Validated for coagulation, inflammation, and angiogenesis research
• Biotechnology grade; RUO designation
• Stored at -20C for optimal stability

Indication for Use:
This product is for Research Use Only. It is not intended for human or animal use, diagnostic procedures, or therapeutic applications.

References Related to High Molecular Weight Kininogen

• Ponczek MB. Structural insights into high molecular weight kininogen. Int J Mol Sci. 2021;22(24):13370.
• Droll SH et al. HK processing during pregnancy. Rapid Commun Mass Spectrom. 2020;34 Suppl 1:e8552.
• Hofman ZLM et al. HK in lethal endotoxemia. J Thromb Haemost. 2018;16(2):193195.
• Zamolodchikov D et al. HK accumulation in Alzheimers disease. Alzheimers Dement. 2022;18(10):19191929.
• Sparkenbaugh EM et al. HK in sickle cell disease. J Thromb Haemost. 2020;18(9):23292340.
• Guo YL, Colman RW. Dual roles of HK in angiogenesis. J Thromb Haemost. 2005;3(4):670676.
• Turk B et al. HK binding to cysteine proteinases. FEBS Lett. 1996;391(12):109112.
• Isordia-Salas I et al. HK in intestinal inflammation. Arch Med Res. 2004;35(5):369377.
• McCrae KR et al. HKa inhibits angiogenesis. Curr Cancer Drug Targets. 2005;5(7):519528.
• Ishimaru F, Hayashi H. HK deficiency. Ryoikibetsu Shokogun Shirizu. 1998;(21 Pt 2):434436.