Description
METTL16 Human Recombinant
| Catalog number: | B2017456 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 100 g |
| Molecular Weight or Concentration: | 64.5 kDa |
| Supplied as: | Solution |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -80C |
| Keywords: | EC 2.1.1.346, EC 2.1.1.62, Methyltransferase-Like Protein 16, Methyltransferase 10 Domain-Containing Protein, N6-Adenosine-Methyltransferase METTL16, Putative Methyltransferase METT10D, U6 Small Nuclear RNA (adenine-(43)-N(6))-Methyltransferase, U6 snRNA Methyltransferase METT10D |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Zeng X, Zhao F, Cui G, Zhang Y, Deshpande RA, Chen Y, Deng M, Kloeber JA, Shi Y, Zhou Q, Zhang C, Hou J, Kim W, Tu X, Yan Y, Xu Z, Chen L, Gao H, Guo G, Liu J, Zhu Q, Cao Y, Huang J, Wu Z, Zhu S, Yin P, Luo K, Mer G, Paull TT, Yuan J, Tao K, Lou Z. METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma Nat Cancer. 2022 Sep;3(9):1088-1104.
- Warda AS, Kretschmer J, Hackert P, Lenz C, Urlaub H, Hbartner C, Sloan KE, Bohnsack MT. Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs EMBO Rep. 2017 Nov;18(11):2004-2014.
- Shima H, Matsumoto M, Ishigami Y, Ebina M, Muto A, Sato Y, Kumagai S, Ochiai K, Suzuki T, Igarashi K. S-Adenosylmethionine Synthesis Is Regulated by Selective N(6)-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1 Cell Rep. 2017 Dec 19;21(12):3354-3363.
- Chen PB, Shi GX, Liu T, Li B, Jiang SD, Zheng XF, Jiang LS. Oxidative Stress Aggravates Apoptosis of Nucleus Pulposus Cells through m(6)A Modification of MAT2A Pre-mRNA by METTL16 Oxid Med Cell Longev. 2022 Jan 11;2022:4036274.
- Brown JA, Kinzig CG, DeGregorio SJ, Steitz JA. Methyltransferase-like protein 16 binds the 3-terminal triple helix of MALAT1 long noncoding RNA Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14013-14018.
- Ishigami Y, Ohira T, Isokawa Y, Suzuki Y, Suzuki T. A single m(6)A modification in U6 snRNA diversifies exon sequence at the 5 splice site Nat Commun. 2021 May 28;12(1):3244.
- Su R, Dong L, Li Y, Gao M, He PC, Liu W, Wei J, Zhao Z, Gao L, Han L, Deng X, Li C, Prince E, Tan B, Qing Y, Qin X, Shen C, Xue M, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen CW, Huang W, Horne D, Rosen ST, He C, Chen J. METTL16 exerts an m(6)A-independent function to facilitate translation and tumorigenesis Nat Cell Biol. 2022 Feb;24(2):205-216.
- Zhang H, Yin M, Huang H, Zhao G, Lu M. METTL16 in human diseases: What should we do next? Open Med (Wars). 2023 Nov 30;18(1):20230856.
- Sun L, Zhang Y, Yang B, Sun S, Zhang P, Luo Z, Feng T, Cui Z, Zhu T, Li Y, Qiu Z, Fan G, Huang C. Lactylation of METTL16 promotes cuproptosis via m(6)A-modification on FDX1 mRNA in gastric cancer Nat Commun. 2023 Oct 20;14(1):6523.
