Description
TMPRSS2 Human Recombinant
| Catalog number: | B2016914 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 10 g |
| Molecular Weight or Concentration: | 29.4 kDa |
| Supplied as: | Solution |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -80C |
| Keywords: | Epitheliasin, PRSS10, Serine Protease 10, Transmembrane Protease Serine 2, Transmembrane Serine Protease 2 |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- TMPRSS2 enzymatic activity SARS-CoV-2 Assays [Internet]. Bethesda (MD): National Center for Advancing Translational Sciences (NCATS); 2020.
- Saunders N, Fernandez I, Planchais C, Michel V, Rajah MM, Baquero Salazar E, Postal J, Porrot F, Guivel-Benhassine F, Blanc C, Chauveau-Le Friec G, Martin A, Grzelak L, Oktavia RM, Meola A, Ahouzi O, Hoover-Watson H, Prot M, Delaune D, Cornelissen M, Deijs M, Meriaux V, Mouquet H, Simon-Lorire E, van der Hoek L, Lafaye P, Rey F, Buchrieser J, Schwartz O. TMPRSS2 is a functional receptor for human coronavirus HKU1 Nature. 2023 Dec;624(7990):207-214.
- Essalmani R, Jain J, Susan-Resiga D, Andro U, Evagelidis A, Derbali RM, Huynh DN, Dallaire F, Laporte M, Delpal A, Sutto-Ortiz P, Coutard B, Mapa C, Wilcoxen K, Decroly E, Nq Pham T, Cohen A, Seidah NG. Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity J Virol. 2022 Apr 27;96(8):e0012822.
- Wang TH, Huang KY, Chen CC, Chang YH, Chen HY, Hsueh C, Liu YT, Yang SC, Yang PC, Chen CY. PM2.5 promotes lung cancer progression through activation of the AhR-TMPRSS2-IL18 pathway EMBO Mol Med. 2023 Jun 7;15(6):e17014.
- Wettstein L, Kirchhoff F, Mnch J. The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment Int J Mol Sci. 2022 Jan 25;23(3):1351.
- Abbasi AZ, Kiyani DA, Hamid SM, Saalim M, Fahim A, Jalal N. Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2 J Med Virol. 2021 Jul;93(7):4205-4218.
- Zipeto D, Palmeira JDF, Argaaraz GA, Argaaraz ER. ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 Front Immunol. 2020 Oct 7;11:576745.
- Dong M, Zhang J, Ma X, Tan J, Chen L, Liu S, Xin Y, Zhuang L. ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19 Biomed Pharmacother. 2020 Nov;131:110678.
- Metzdorf K, Jacobsen H, Greweling-Pils MC, Hoffmann M, Lddecke T, Miller F, Melcher L, Kempf AM, Nehlmeier I, Bruder D, Widera M, Ciesek S, Phlmann S, iin-ain L. TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection Viruses. 2023 Jan 18;15(2):271.
