Description
Plasmepsin II FRET Substrate
| Catalog number: | B2011261 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 1 mg |
| Molecular Weight or Concentration: | 1896.2 g/mol |
| Supplied as: | Lyophilized |
| Applications: | molecular tool for various biochemical applications |
| Storage: | -20 C |
| Keywords: | Plasmepsin II FRET Substrate, Hemoglobin Fragment |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Liu J, Istvan ES, Goldberg DE. Hemoglobin-degrading plasmepsin II is active as a monomer J Biol Chem. 2006 Dec 15;281(50):38682-8.
- Mohapatra SC, Tiwari HK, Singla M, Rathi B, Sharma A, Mahiya K, Kumar M, Sinha S, Chauhan SS. Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum J Biol Inorg Chem. 2010 Mar;15(3):373-85.
- Silva AM, Lee AY, Gulnik SV, Maier P, Collins J, Bhat TN, Collins PJ, Cachau RE, Luker KE, Gluzman IY, Francis SE, Oksman A, Goldberg DE, Erickson JW. Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10034-9.
- Dan N, Bhakat S. New paradigm of an old target: an update on structural biology and current progress in drug design towards plasmepsin II Eur J Med Chem. 2015 May 5;95:324-48.
- Foguim Tsombeng F, Gendrot M, Robert MG, Madamet M, Pradines B. Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa? Malar J. 2019 Aug 23;18(1):285.
- Corminboeuf O, Dunet G, Hafsi M, Grimont J, Grisostomi C, Meyer S, Binkert C, Bur D, Jones A, Prade L, Brun R, Boss C. Inhibitors of Plasmepsin II-potential antimalarial agents Bioorg Med Chem Lett. 2006 Dec 15;16(24):6194-9.
- Song Y, Jin H, Liu X, Zhu L, Huang J, Li H. Discovery of non-peptide inhibitors of Plasmepsin II by structure-based virtual screening Bioorg Med Chem Lett. 2013 Apr 1;23(7):2078-82.
- Qidwai T, Yadav DK, Khan F, Dhawan S, Bhakuni RS. QSAR, docking and ADMET studies of artemisinin derivatives for antimalarial activity targeting plasmepsin II, a hemoglobin-degrading enzyme from P. falciparum Curr Pharm Des. 2012;18(37):6133-54.
- Ersmark K, Samuelsson B, Hallberg A. Plasmepsins as potential targets for new antimalarial therapy Med Res Rev. 2006 Sep;26(5):626-66.
