-Defensin-2 (Human)

Description

-Defensin-2 (Human)

-Defensin-2 (Human) is a biotechnology-grade antimicrobial peptide derived from human neutrophils. With a molecular weight of 3370.8 g/mol, this 29-residue peptide features a conserved disulfide array that stabilizes its -sheet-rich structure, enabling potent bactericidal activity. Its sequence includes multiple arginine and cysteine residues, contributing to membrane disruption and immune modulation. Supplied as a 100 g powder aliquot, it is ideal for in vitro studies of innate immunity, epithelial defense, and cytokine induction.

Defensins are critical components of the human immune system, acting as natural antibiotics against bacteria, fungi, and viruses. -Defensin-2 has been shown to influence dendritic cell activation, T-cell recruitment, and inflammatory signaling. It is widely used in dermatological, gastrointestinal, and virology research, particularly in studies of barrier function and mucosal immunity. This reagent is stable at -20C and should be reconstituted in sterile buffer prior to use. All components are highly pure and RUO-compliantthis product is not intended for human or animal use.

Key benefits:

• Biotechnology-grade purity for reproducible in vitro assays
• Stabilized disulfide array for structural integrity and activity
• Validated in immunology, virology, and epithelial defense studies
• Stable at -20C; powder format for flexible reconstitution
• RUO-compliant: not for clinical or veterinary use

Indication for Use:
This product is for Research Use Only (RUO). It is not intended for human or animal use, diagnostic procedures, or therapeutic applications.

References:

• Oppenheim, J. J., Yang, D., & Biragyn, A. (2003). The role of defensins in innate immunity. Journal of Immunology, 171(3), 12311236.
• Yang, D., Chertov, O., Bykovskaia, S. N., et al. (2000). Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Journal of Immunology, 165(8), 48744880.
• Niyonsaba, F., Ushio, H., & Ogawa, H. (2005). The human antimicrobial peptide LL-37 induces the production of pro-inflammatory cytokines in human keratinocytes. Journal of Dermatological Science, 40(2), 113121.
• Koczulla, A. R., & Bals, R. (2003). Antimicrobial peptides: the LPS connection. Nature Reviews Microbiology, 1(1), 18.
• Schittek, B., & Huber, M. (2003). The role of defensins in the skin. Journal of Investigative Dermatology, 121(5), 10971102.
• Wang, Z., & Wang, G. (2004). APD: the Antimicrobial Peptide Database. Nucleic Acids Research, 32(Database issue), D590D592.
• Kearney, C. J., & ONeill, L. A. J. (2006). The role of defensins in the immune response. Nature Reviews Immunology, 6(3), 211220.
• Huttner, K. M., & Huber, M. (2008). The role of defensins in the pathogenesis of inflammatory bowel disease. Inflammatory Bowel Diseases, 14(1), 110.
• Karp, C. L., & Kauffman, H. M. (2005). The role of defensins in the immune response to viral infections. Journal of Virology, 79(12), 74657472.
• Xie C, Zeng P, Ericksen B, Wu Z, Lu WY, Lu W. Effects of the terminal charges in human neutrophil alpha-defensin 2 on its bactericidal and membrane activity. Peptides. 2005 Dec;26(12):237783.