Description
Human RNAse l Wild type Recombinant Protein
| Catalog number: | B2012582 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 10 ug |
| Molecular Weight or Concentration: | 15.79 kDa |
| Supplied as: | Solution |
| Applications: | molecular tool for various biochemical applications |
| Storage: | -20C |
| Keywords: | RNAse l Wild type, ribonuclease, RNase A family, 1 (pancreatic) |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Zhang A, Dong B, Doucet AJ, Moldovan JB, Moran JV, Silverman RH. RNase L restricts the mobility of engineered retrotransposons in cultured human cells Nucleic Acids Res. 2014 Apr;42(6):3803-20.
- Li Y, Banerjee S, Wang Y, Goldstein SA, Dong B, Gaughan C, Silverman RH, Weiss SR. Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2241-6.
- Al-Ahmadi W, Al-Haj L, Al-Mohanna FA, Silverman RH, Khabar KS. RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth Oncogene. 2009 Apr 16;28(15):1782-91.
- Jha BK, Polyakova I, Kessler P, Dong B, Dickerman B, Sen GC, Silverman RH. Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity J Biol Chem. 2011 Jul 29;286(30):26319-26.
- Siddiqui MA, Malathi K. RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways J Biol Chem. 2012 Dec 21;287(52):43651-64.
- Sorgeloos F, Jha BK, Silverman RH, Michiels T. Evasion of antiviral innate immunity by Theilers virus L* protein through direct inhibition of RNase L PLoS Pathog. 2013;9(6):e1003474.
- Whelan JN, Li Y, Silverman RH, Weiss SR. Zika Virus Production Is Resistant to RNase L Antiviral Activity J Virol. 2019 Jul 30;93(16):e00313-19.
- Banerjee S, Gusho E, Gaughan C, Dong B, Gu X, Holvey-Bates E, Talukdar M, Li Y, Weiss SR, Sicheri F, Saunthararajah Y, Stark GR, Silverman RH. OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5071-5076.
- Zhao L, Jha BK, Wu A, Elliott R, Ziebuhr J, Gorbalenya AE, Silverman RH, Weiss SR. Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology Cell Host Microbe. 2012 Jun 14;11(6):607-16.
