Description
Rat Recombinant Thioredoxin Reductase 1 (aa 3-499)
| Catalog number: | B2016937 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 5 U |
| Molecular Weight or Concentration: | 54.5 kDa |
| Supplied as: | Solution |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -80C |
| Keywords: | NADPH-dependent Thioredoxin Reductase, TrxR1, Txnrd1 |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Cheng P, Liu H, Li Y, Pi P, Jiang Y, Zang S, Li X, Fu A, Ren X, Xu J, Holmgren A, Lu J. Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury Biochem Pharmacol. 2020 May;175:113873.
- Wang L, Yang Z, Fu J, Yin H, Xiong K, Tan Q, Jin H, Li J, Wang T, Tang W, Yin J, Cai G, Liu M, Kehr S, Becker K, Zeng H. Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent Free Radic Biol Med. 2012 Mar 1;52(5):898-908.
- Dagnell M, Pace PE, Cheng Q, Frijhoff J, stman A, Arnr ESJ, Hampton MB, Winterbourn CC. Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H(2)O(2) exposure J Biol Chem. 2017 Sep 1;292(35):14371-14380.
- Rengby O, Cheng Q, Vahter M, Jrnvall H, Arnr ES. Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1 Free Radic Biol Med. 2009 Apr 1;46(7):893-904.
- Cheng Q, Sandalova T, Lindqvist Y, Arnr ES. Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1 J Biol Chem. 2009 Feb 6;284(6):3998-4008.
- Engelman R, Ziv T, Arnr ESJ, Benhar M. Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance Free Radic Biol Med. 2016 Aug;97:375-385.
- Peng X, Zhang MQ, Conserva F, Hosny G, Selivanova G, Bykov VJ, Arnr ES, Wiman KG. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase Cell Death Dis. 2013 Oct 24;4(10):e881.
- Gencheva R, Cheng Q, Arnr ESJ. Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase Biochim Biophys Acta Gen Subj. 2018 Nov;1862(11):2511-2517.
- Jovanovi M, Zhukovsky D, Podolski-Reni A, Domraeva I, alubovskis R, Senanski M, Glii S, Sharoyko V, Tennikova T, Darin D, Pei M, Krasavin M. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy Eur J Med Chem. 2019 Nov 1;181:111580.
