Description
SARS-CoV-2 Papain-like Protease
| Catalog number: | B2017053 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 50 g |
| Molecular Weight or Concentration: | 36.8 kDa |
| Supplied as: | Powder |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -80C |
| Keywords: | 2019-nCoV Plpro, COVID-19-Plpro, SARS-CoV-2 Plpro, Severe Acute Respiratory Syndrome Coronavirus 2 Papain-like Protease |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Ullrich S, Nitsche C. SARS-CoV-2 Papain-Like_Protease: Structure, Function and Inhibition Chembiochem. 2022 Oct 6;23(19):e202200327.
- Ton AT, Pandey M, Smith JR, Ban F, Fernandez M, Cherkasov A. Targeting SARS-CoV-2 papain-like_protease in the postvaccine era Trends Pharmacol Sci. 2022 Nov;43(11):906-919.
- Jiang H, Yang P, Zhang J. Potential Inhibitors Targeting Papain-Like_Protease of SARS-CoV-2: Two Birds With One Stone Front Chem. 2022 Feb 23;10:822785.
- Liu G, Lee JH, Parker ZM, Acharya D, Chiang JJ, van Gent M, Riedl W, Davis-Gardner ME, Wies E, Chiang C, Gack MU. ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2_papain-like_protease to evade host innate immunity Nat Microbiol. 2021 Apr;6(4):467-478.
- Cao D, Duan L, Huang B, Xiong Y, Zhang G, Huang H. The SARS-CoV-2 papain-like_protease suppresses type I interferon responses by deubiquitinating STING Sci Signal. 2023 May 2;16(783):eadd0082.
- Gao X, Qin B, Chen P, Zhu K, Hou P, Wojdyla JA, Wang M, Cui S. Crystal structure of SARS-CoV-2 papain-like_protease Acta Pharm Sin B. 2021 Jan;11(1):237-245.
- Stasiulewicz A, Maksymiuk AW, Nguyen ML, Beza B, Sulkowska JI. SARS-CoV-2_Papain-Like_Protease Potential Inhibitors-In Silico Quantitative Assessment Int J Mol Sci. 2021 Apr 12;22(8):3957.
- Tan H, Hu Y, Jadhav P, Tan B, Wang J. Progress and Challenges in Targeting the SARS-CoV-2_Papain-like_Protease J Med Chem. 2022 Jun 9;65(11):7561-7580.
- Valipour M. Chalcone-amide, a privileged backbone for the design and development of selective SARS-CoV/SARS-CoV-2 papain-like protease inhibitors Eur J Med Chem. 2022 Oct 5;240:114572.
