Description
4′-demethylepipodophyllotoxin
| Catalog number: | B2015852 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 5 g |
| Molecular Weight or Concentration: | 400.38 g/mol |
| Supplied as: | Powder |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | RT |
| Keywords: | 4-DMEP |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Lu Y, Zhu L, Cai R, Li Y, Zhao Y. 2, 4, 5-Trideoxyhexopyranosides Derivatives of 4-Demethylepipodophyllotoxin: De novo Synthesis and Anticancer Activity Med Chem. 2022;18(1):130-139.
- Etoposide 2021 Jan 18. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
- Zhao W, Duan Y, Li HM, Li S, Shen Y, Zhang Y, Li YZ, Tang YJ. Triazole/thiadiazole substituted 4-demethylepipodophyllotoxin_derivatives induced apoptosis in HeLa cells by up-regulating TMEM133 Eur J Pharmacol. 2021 Aug 15;905:174189.
- Zhang QY, Zhao W, Tang YJ. Discover the leading compound of 4-S-(5-fluorobenzoxazole)-4-deoxy-4-demethylepipodophyllotoxin_with millimolar-potency toxicity by modifying the molecule structure of 4-demethylepipodophyllotoxin_Eur J Med Chem. 2018 Oct 5;158:951-964.
- Zhao W, Li HM, Wan DJ, Tang YJ. Manipulation of heterogeneity product in 4-demethylepipodophyllotoxin_biotransformation process by using yeast extract as nitrogen source Appl Microbiol Biotechnol. 2012 Jan;93(1):107-15.
- Xie KB, Chen RD, Zhang YJ, Chen DW, Dai JG. [Enzymatic glycosylation of 4-demethylepipodophyllotoxin] Zhongguo Zhong Yao Za Zhi. 2017 Jun;42(12):2323-2328.
- Niu L, Wang Y, Wang C, Wang Y, Jiang X, Ma L, Wu C, Yu Y, Chen Q. Structure of 4-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design Biochem Biophys Res Commun. 2017 Nov 4;493(1):718-722.
- Zhao W, Chen L, Li HM, Wang DJ, Li DS, Chen T, Yuan ZP, Tang YJ. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation Bioorg Med Chem. 2014 Jun 1;22(11):2998-3007.
- Cheng J, Zhao W, Yao H, Shen Y, Zhang Y, Li YZ, Qi Q, Wongprasert K, Tang YJ. Discovery of 4,6-O-Thenylidene–d-glucopyranoside-(2-acetamido, 3-acetyl-di-S-5-fluorobenzothizole/5-fluorobenzoxazole)-4-demethylepipodophyllotoxin as Potential Less Toxic Antitumor Candidate Drugs by Reducing DNA Damage and Less Inhibition of PI3K J Med Chem. 2020 Mar 26;63(6):2877-2893.
