Description
5-TMR-GPHRSTPESRAAV (Presenilin 1 domain)
| Catalog number: | B2019419 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 1 mg |
| Molecular Weight or Concentration: | 1777 |
| Supplied as: | Powder |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -20C |
| Keywords: | GPHRSTPESRAAV, 5 TMR labeled |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Duggan SP, Yan R, McCarthy JV. A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains FEBS Lett. 2015 Apr 13;589(9):1001-8.
- Shen T, Shi J, Zhao X, Fu L, Wang N, Zheng X, Chen Y, Li M, Ma C, Liu P, Zhu D. Presenilin 1 Is a Therapeutic Target in Pulmonary Hypertension and Promotes Vascular Remodeling Am J Respir Cell Mol Biol. 2024 Jun;70(6):468-481.
- Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type -secretase modulators target the transmembrane domain 1 of presenilin 1 EMBO J. 2011 Oct 14;30(23):4815-24.
- Laudon H, Hansson EM, Meln K, Bergman A, Farmery MR, Winblad B, Lendahl U, von Heijne G, Nslund J. A nine-transmembrane domain topology for presenilin 1 J Biol Chem. 2005 Oct 21;280(42):35352-60.
- Saftig P, Hartmann D, De Strooper B. The function of presenilin-1 in amyloid beta-peptide generation and brain development Eur Arch Psychiatry Clin Neurosci. 1999;249(6):271-9.
- Edwards-Lee T, Wen J, Bell J, Hardy J, Chung J, Momeni P. A presenilin-1 mutation (T245P) in transmembrane domain 6 causes early onset Alzheimers disease Neurosci Lett. 2006 May 8;398(3):251-2.
- Viswanathan J, Haapasalo A, Bttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. Alzheimers disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation Traffic. 2011 Mar;12(3):330-48.
- Borchelt DR. Metabolism of presenilin 1: influence of presenilin 1 on amyloid precursor protein processing Neurobiol Aging. 1998 Jan-Feb;19(1 Suppl):S15-8.
- Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions EMBO J. 2002 Apr 15;21(8):1948-56.
