Description
Human Prothrombin witout GLA Domain
| Catalog number: | B2013215 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 5 mg |
| Molecular Weight or Concentration: | na |
| Supplied as: | Solution |
| Applications: | molecular tool for various biochemical applications |
| Storage: | -20 C |
| Keywords: | Human Prothrombin-gla domainless |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Winter WE, Flax SD, Harris NS. Coagulation Testing in the Core Laboratory Lab Med. 2017 Nov 8;48(4):295-313.
- Blostein MD, Rigby AC, Jacobs M, Furie B, Furie BC. The Gla domain of human prothrombin has a binding site for factor Va J Biol Chem. 2000 Dec 1;275(48):38120-6.
- Tokunaga F, Takeuchi S, Omura S, Arvan P, Koide T. Secretion, gamma-carboxylation, and endoplasmic reticulum-associated degradation of chimeras with mutually exchanged Gla domain between human protein C and prothrombin Thromb Res. 2000 Sep 1;99(5):511-21.
- Wu W, Bancroft JD, Suttie JW. Structural features of the kringle domain determine the intracellular degradation of under-gamma-carboxylated prothrombin: studies of chimeric rat/human prothrombin Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13654-60.
- Card DJ, Gorska R, Harrington DJ. Laboratory assessment of vitamin K status J Clin Pathol. 2020 Feb;73(2):70-75.
- Itoh S, Yokoyama R, Kamoshida G, Fujiwara T, Okada H, Takii T, Tsuji T, Fujii S, Hashizume H, Onozaki K. Staphylococcal superantigen-like protein 10 (SSL10) inhibits blood coagulation by binding to prothrombin and factor Xa via their -carboxyglutamic acid (Gla) domain J Biol Chem. 2013 Jul 26;288(30):21569-80.
- Soriano-Garcia M, Park CH, Tulinsky A, Ravichandran KG, Skrzypczak-Jankun E. Structure of Ca2+ prothrombin fragment 1 including the conformation of the Gla domain Biochemistry. 1989 Aug 22;28(17):6805-10.
- Qureshi SH, Yang L, Manithody C, Bae JS, Rezaie AR. Functional properties and active-site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C Biochim Biophys Acta. 2008 Sep;1780(9):1080-6.
- Li L, Darden T, Hiskey R, Pedersen LG. Computational studies of human prothrombin fragment 1, the Gla domain of factor IX and several biological interesting mutants Haemostasis. 1996;26 Suppl 1:54-9.
